4) IMO 401ks are a ripoff created by the banks for the banks. But, that doesn’t mean you have to stay in them. Roll over to a self directed IRA.
Vanguard, the leader in no-load, low expense funds, believes that advisers are worth about 3% of your AUM for the value that they provide. Interesting….
If you have a tough time linking your accounts online, then you are probably a great client for UBS. The sub 35 age group are super adopters of technology, and this is the demographic that businesses are looking to penetrate.
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This forces the second-level linebackers to flow play-side versus the center/tackle and allows Vick to ride McCoy through the mesh point while reading the unblocked defensive end/tackle to the open side.
With the second-level linebackers now removed, and the defensive end/tackle crashing inside to McCoy at the mesh point, Vick can pull the ball and attack the running lane to the open side of the formation.
Click here for a breakdown of the Power-Running Game
And because of the late run fill from the safety in the alley, Vick can take this ball across the goal line for six points.
As you can see from the tape, quarterback Cam Newton read the defensive end through the mesh point, with the backside guard pulling to the play side to work to the second level of the defense.
Up Next in the “NFL 101” Series: Packaged Plays
In today’s installment of the “NFL 101” series at Bleacher Report, former NFL defensive back Matt Bowen breaks down the basics of the read-option to give you a better understanding of scheme and execution at the pro level.
In last week’s “NFL 101” breakdown, we looked at the core concepts in the zone-running game to highlight the blocking techniques along the offensive line (“zone step”) that counter multiple defensive fronts in both the inside and outside zone schemes.
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Cover-All Technologies is in the business of providing software products and services for the property and casualty insurance space. That sector has been getting headlines this year with the uptick in natural disasters and inclement weather. Any chance to save money with technology will be more likely to be advanced under more difficult financial times.
Mind CTI (NASDAQ: MNDO ) is an Israeli-based technology company that provides convergent end-to-end billing and customer-care product-based solutions for service providers as well as telecom expense management solutions. After peaking at nearly $3.60 per share, the stock has slipped to current levels at $2.80 per share.
Because these companies have the wind at their sails from an earnings perspective, these penny stock prices will not last long. Now is the time to pounce before the rest of the market catches on.
From 2012 to 2015, he served as an Instructor at West Point.
Some do not see the need for this work. Some argue that since our actions are not as horrifying as Al Qaeda's, we should not be concerned. When did Al Qaeda become any type of standard by which we measure the morality of the United States? We are America, and our actions should be held to a higher standard, the ideals expressed in documents such as the Declaration of Independence and the Constitution.
Fishback expressed concern about what he perceived as a military culture that was permissive toward the abuse of prisoners.
Instead of resolving my concerns, the approach for clarification process leaves me deeply troubled. Despite my efforts, I have been unable to get clear, consistent answers from my leadership about what constitutes lawful and humane treatment of detainees. I am certain that this confusion contributed to a wide range of abuses including death threats, beatings, broken bones, murder, exposure to elements, extreme forced physical exertion, hostage-taking, stripping, sleep deprivation and degrading treatment. I and troops under my command witnessed some of these abuses in both Afghanistan and Iraq.
Others argue that clear standards will limit the President's ability to wage the War on Terror. Since clear standards only limit interrogation techniques, it is reasonable for me to assume that supporters of this argument desire to use coercion to acquire information from detainees. This is morally inconsistent with the Constitution and justice in war. It is unacceptable.
Ian Fishback is a former United States Army officer, who became known after he sent a letter to Senator John McCain of Arizona on September 16, 2005, in which Fishback stated his concerns about the continued abuse of prisoners held under the auspices of the Global War on Terror.
Fishback was chosen by TIME magazine as one of the 100 most influential people in the world on May 8, 2006 for taking the stand against torture.
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Federation allows customers to use Active Directory-based domain user accounts to access Microsoft Online Services such as Office 365 or Microsoft Dynamics 365 (online). After federation is configured by an administrator, Active Directory-based system user accounts can be locally managed, made available to Microsoft Online Services, and kept in sync with changes made to the on-premises Active Directory identities. The benefit of federation is a single sign-on experience across Microsoft Dynamics 365 (on-premises) and Microsoft Dynamics 365 (online) systems. This type of identity management is useful for large corporations that have hundreds or thousands of established users.
For more information about how to configure identity federation, see Single sign-on: Roadmap.
This topic provides information about where users’ identities are created and managed, and how they relate to Microsoft Dynamics 365 (online).
All Microsoft Dynamics 365 (online) customers with Microsoft account subscriptions are being transitioned to a Microsoft Office 365/Microsoft Online Services subscription. In this release of the SDK, several authentication-related classes have been updated to ease this transition by supporting Microsoft account logon credentials when you authenticate with the Microsoft Online Services identity provider of Microsoft Dynamics 365 (online). Depending on the SDK classes used by your application to authenticate, you may or may not need to update your application code to support transitioned users.
6 Ways to Overcome Job Interview Anxiety
Please note how the rule A + 1 = 1 was used to reduce the (B + 1) term to 1. When a rule like “A + 1 = 1” is expressed using the letter “A”, it doesn’t mean it only applies to expressions containing “A”. What the “A” stands for in a rule like A + 1 = 1 is any Boolean variable or collection of variables. This is perhaps the most difficult concept for new students to master in Boolean simplification: applying standardized identities, properties, and rules to expressions not in standard form.
To summarize, here are the three new rules of Boolean simplification expounded in this section:
The next rule looks similar to the first one shown in this section, but is actually quite different and requires a more clever proof:
Another rule involves the simplification of a product-of-sums expression:
This rule may be proven symbolically by factoring an “A” out of the two terms, then applying the rules of A + 1 = 1 and 1A = A to achieve the final result:
Published under the terms and conditions of the Design Science License
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eToro is a social trading and multi asset brokerage company that has registered offices in Cyprus, Israel and the United Kingdom.
Peterffy has described the company as similar to Charles Schwab Corporation or TD Ameritrade, however specializing in providing brokerage services to larger customers and charging low transaction costs. He also described the company's focus on building technology over having high sales, with technology often used to automate systems in order to service customers at a low cost. 32 The company can afford to focus on automation and acquiring customers over focusing on financial results, as 84% of the company is held by employees. 33 It has offered direct market access to Australian contracts for difference since 2008. 34 Mobile transactions account for about 10% of the company's retail orders. 35 Investors can open online accounts, which require $10,000 invested; individual retirement accounts require $5,000 and clients under age 26 require $3,000. 36 Monthly trading commissions for most accounts are $10 a month, with an activity fee charged if the minimum commissions are not met. 37 New customers are directed towards Traders' University, the company's education resource, which includes series of a webinars and videos on IB's products and trading tools. 35 Interactive Brokers has systems that prevent traders from violating trading regulations, including by preventing customers from pattern day trading. 38
In 1983, Peterffy sought to computerize the options market, and he first targeted the Chicago Board Options Exchange (CBOE). 4 At the time, brokers still used fair value pricing sheets, which were by then updated once or twice a day. In 1983, Timber Hill created the first handheld computers used for trading. As Peterffy explained in a 2016 interview, the battery-powered units had touch screens for the user to input a stock price and it would produce the recommended option prices, 6 7 and it also tracked positions and continually repriced options on stocks. 8 However, he immediately encountered opposition from the heads of the exchange. When he first brought a 12-inch-long (30 cm) by 9-inch-wide (23 cm) device to the exchange floor, a committee in the exchange told him it was too big. When he made the device smaller, the committee stated that no analytic devices were allowed to be used on the exchange floor. Effectively blocked from using the CBOE, he sought to use his devices in other exchanges. 4
Interactive Brokers LLC (IB) is a U.S.-based electronic brokerage firm. It is the largest U.S. electronic brokerage firm by number of daily average revenue trades, and is the leading forex broker. The company brokers stocks, options, futures, EFPs, futures options, forex, bonds, funds and CFDs. Interactive Brokers also services commodity trading advisors (CTAs), making it the fifth-largest prime broker servicing CTAs.
In 1987, Timber Hill joined the National Securities Clearing Corporation and the Depository Trust Company (now merged as the Depository Trust & Clearing Corporation). By 1987, Timber Hill had 67 employees and had become self-clearing in equities. 8 In 1987, the CBOE was about to close down its S&P 500 options market due to the options not attracting sufficient trader interest. Because of this, Peterffy pledged that Timber Hill would make tight markets in the product for a year if the exchange would allow the traders to use handheld computers on the trading floor. The exchange agreed, and more traders were attracted by the change in pricing; today S&P 500 options are the most actively traded index options in the U.S. 4 In 1990, Timber Hill Deutschland GmbH was incorporated in Germany, and shortly thereafter began trading equity derivatives at the Deutsche Terminborse (DTB), marking the first time that Timber Hill used one of its trading systems on a fully automated exchange. In 1992, Timber Hill began trading at the Swiss Options and Financial Futures Exchange, which merged with DTB in 1998 to become Eurex. At that time, Timber Hill had 142 employees. 8
Among the company's directors are Lawrence E. Harris, a professor at the University of Southern California's Marshall School of Business, and who was Chief Economist of the Securities and Exchange Commission. 40 Among its former directors are Hans Stoll, founder and director of the Financial Markets Research Center at Vanderbilt University, and an author and former president of the American Finance Association, 1 (p22) 41 and Ivers Riley, former chairman of the International Securities Exchange, CEO of the Hong Kong Futures Exchange, and chief developer of SPDR funds. 42
In 2001, the corporate name of the Timber Hill Group LLC was changed to Interactive Brokers Group LLC, which at the time handled 200,000 trades per day. In 2002, Interactive Brokers, along with the Bourse de Montréal and the Boston Stock Exchange, created the Boston Options Exchange. 11 Also in 2002, IB introduced Mobile Trader and an application programming interface for customers and developers to integrate their mobile phone systems with the IB trading system. 12 In 2002, Timber Hill became the major market maker for the newly introduced U.S. single-stock futures. In 2003, Interactive Brokers expanded its trade execution and clearing services to include Belgian index options and futures, Canadian stocks, equity/index options and futures, Dutch index options and futures, German equity options, Italian index options and futures, Japanese index options and futures, and U.K. equity options. In 2004, IB introduced direct market access to its customers on the Frankfurt and Stuttgart exchanges. In the same year, IB upgraded its account management system and Trader Workstation, adding real-time charts, scanners, fundamental analytics, and tools BookTrader and OptionTrader to the platform. In 2005, IB released its forex trading platform IdealPro (now Ideal FX). In 2006, the IB Options Intelligence Report was launched to report on unusual concentrations of trading interests and changing levels of uncertainty in the option markets. Also in that year, IBG took stakes in OneChicago, the ISE Stock Exchange, and the CBOE Stock Exchange. In 2006, Interactive Brokers started offering penny-priced options. 8 13
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The antigenic molecules that activate gamma delta T cells are still largely unknown. However, γδ T cells are peculiar in that they do not seem to require antigen processing and major-histocompatibility-complex (MHC) presentation of peptide epitopes, although some recognize MHC class Ib molecules. Furthermore, γδ T cells are believed to have a prominent role in recognition of lipid antigens. They are of an invariant nature and may be triggered by alarm signals, such as heat shock proteins (HSP).
Clearly, the complexity of gamma delta T cell biology spans definitions of both innate and adaptive immune responses.
Like other 'unconventional' T cell subsets bearing invariant TCRs, such as CD1d-restricted Natural Killer T cells, gamma delta T cells exhibit several characteristics that place them at the border between the more evolutionarily primitive innate immune system that permits a rapid beneficial response to a variety of foreign agents, and the adaptive immune system, where B and T cells coordinate a slower but highly antigen-specific immune response leading to long-lasting memory against subsequent challenges by the same antigen.
Vγ9/Vδ2 T cells are unique to humans and primates and represent a minor and unconventional constituent of the leukocyte population in peripheral blood (0.5-5%); yet they are assumed to play an early and essential role in sensing 'danger' by invading pathogens as they expand dramatically in many acute infections and may exceed all other lymphocytes within a few days, e.g. in tuberculosis, salmonellosis, ehrlichiosis, brucellosis, tularemia, listeriosis, toxoplasmosis, and malaria. Of note, all Vγ9/Vδ2 T cells recognize the same small microbial compound (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP), a natural intermediate of the non-mevalonate pathway of isopentenyl pyrophosphate (IPP) biosynthesis. 11 HMB-PP is an essential metabolite in most pathogenic bacteria including Mycobacterium tuberculosis and malaria parasites, but is absent from the human host. Bacterial species that lack the non-mevalonate pathway and synthesize IPP via the classical mevalonate pathway instead, such as Streptococcus, Staphylococcus, and Borrelia, are unable to produce HMB-PP and do not specifically activate Vγ9/Vδ2 T cells.
These Vγ9Vδ2 T cells can also behave like professional antigen-presenting cells (APC). It seems that human Vγ9Vδ2 T cells are characterized by a specific inflammatory migration program, including multiple receptors for inflammatory chemokines (CXCR3, CCR1, CCR2 and CCR5). It means that the stimulation with IPP or HMB-PP induces migration to the lymphatic tissues, specifically to the T cell area of lymph nodes. So the stimulation of Vγ9Vδ2 T cells with phosphoantigens results in expression of multiple markers which are associated with APC, like MHC I and II molecules, co-stimulatory molecules (CD80, CD86) and adhesion receptors (CD11a, CD18, CD54). Thus activated Vγ9Vδ2 T cells behave like APCs (γδ T-APC) and present antigens to αβ T cells. This leads to turn of naïve CD4+ and CD8+ αβ T cells into effector cells. The differentiation, induced by γδ T-APC, most often led to T helper cell response, in the most of cases to pro-inflammatory Th1 response with subsequent production of IFN-γ and TNF-α. But in the case of a low γδ T-APC: CD4+ ratio it leads to differentiation of some naïve αβ T cells into Th2 (IL-4) or Th0 (IL-4 plus IFN-γ) cells. Human Vγ9Vδ2 T cells are also cells with excellent antigen cross-presentation activity, a process describing the uptake of exogenous antigen and its routing to the MHC I pathway for induction CD8+ cytotoxic T cells. Thus activated cytotoxic T cells can effectively kill infected or tumor cells. This fact can be used in the immunotherapy of cancer and infectious diseases. 13
This table summarizes the nomenclature of mouse Vγ chains and indicates monoclonal antibodies often used to identify these chains. This system has been best described in strain C57BL/6 and might not apply well to other strains. There are two systems of nomenclature in use (Heilig; Garman), and many writers do not indicate which system they use. For example, the IMGT (International Immunogenetics Information System) uses the Heilig notation, but does not indicate this fact on its website. 7 This table refers to variable chain Vγ gene segments and to monoclonal antibodies that detect the corresponding Vγ protein chains. Note that Adrian Hayday's proposed nomenclature is not widely used, citation needed leaving considerable confusion in the literature. One advantage and weakness of the Hayday nomenclature is that it is based on the gene order in the B6 genome, but this might not apply to other strains.
Non-Vδ2 γδ T cells are expanded in various infectious contexts involving intracellular bacteria (Mycobacteria and Listeria) as well as extracellular bacteria, such as Borrelia burgdorferi and viruses (HIV, cytomegalovirus). In most instances, the stimuli that trigger Vd1 expansion are not derived from pathogens but instead correspond to endogenous gene products presumably upregulated on infection. The antigens recognized by non-Vδ2 T cells expanded in the above infectious contexts have not been characterized, but the fact that Vδ1+ T-cell responses are not blocked by monoclonal antibody directed against known classical or non-classical MHC molecules suggests recognition of a new class of conserved stress-induced antigens.
Gamma delta T cells (γδ T cells) are T cells that have a distinctive T-cell receptor (TCR) on their surface. Most T cells are αβ (alpha beta) T cells with TCR composed of two glycoprotein chains called α (alpha) and β (beta) TCR chains. In contrast, gamma delta (γδ) T cells have a TCR that is made up of one γ (gamma) chain and one δ (delta) chain. This group of T cells is usually much less common than αβ T cells, but are at their highest abundance in the gut mucosa, within a population of lymphocytes known as intraepithelial lymphocytes (IELs). 1
Perhaps a massive unseen object is responsible for Sedna’s mystifying orbit, its gravitational influence keeping Sedna fixed in that far-distant portion of space.
Nicknamed “Nemesis” or “The Death Star,” this undetected object could be a red or brown dwarf star, or an even darker presence several times the mass of Jupiter.
Neither Kirkpatrick nor Wright think Nemesis is disrupting the Oort cloud and sending comets towards Earth, however. Because they envision a more benign orbit, they prefer the name "Tyche" (the good sister).
2. Reviews: One quick way of finding out if the broker is trustworthy or not is by going through the reviews of both customers and experts.
5. Customer care: A quality trading broker must have a responsive customer care options to help you out any time. Live chat option should be given priority as it can sort out your queries immediately.
If you are confused how to select a trustworthy broker, run through these points before selecting one.
1. Platform: Make sure that the trading platform of the broker is smooth and responsive. It must have a smooth navigation and must include frequently used options. The platform must be designed is such a way that you are comfortable while trading.